5HT1B Receptor anticorps (N-Term)

N° du produit ABIN2774611

Cet anticorps anti-5HT1B Receptor est un anticorps Lapin Polyclonal détectant 5HT1B Receptor dans WB. Adapté pour Humain.

Aperçu rapide pour 5HT1B Receptor anticorps (N-Term) (ABIN2774611)

Antigène: 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp 5HT1B Receptor est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-5HT1B Receptor anticorps

Épitope: N-Term

Séquence: MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against HTR1B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human HTR1B

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 390 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur 5HT1B Receptor

Antigène: 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))

Autre désignation: HTR1B

Sujet: The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
Alias Symbols: S12, 5-HT1B, HTR1D2, HTR1DB, 5-HT1DB
Protein Interaction Partner: MDFI, HTR1D, HTR1B, HTR1A, GSTK1, NME2,
Protein Size: 390

Poids moléculaire: 44 kDa

ID gène: 3351

NCBI Accession: NM_000863, NP_000854

UniProt: P28222

Pathways: Signalistation JAK/STAT, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, S100 Proteins